Machine running Windows 7 Pro 64 bit. MS Office 2010. Problem is once there is a spreadsheet open and minimized and you click on a second spreadsheet shortcut, it won't open. You will get the blue circle so it is trying. You can do it through file/resent files and open it that way. The shortcut is a file that lives on a server. Other identical machines are set up and have shortcuts to the same files. This is the only one that does that.
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